ELC Series amplifier
npi electronic ELC amplifiers are unique on the market for their ability to combine several recording and stimulation techniques in a single device. They can be used for patch clamp and microelectrode recording, as well as stimulation, dye injection and cell transfection protocols. Each ELC amplifier offers the possibility of identifying a cell in situ using its action potential discharge pattern, then carrying out electro-permeabilisation (electroporation) or stimulating the cell directly. Using the Loose Patch technique, cells can be recorded and stimulated under minimally invasive conditions, including at subcellular levels (dendrites, axons).the integrated preamplifier, based on a resistive feedback circuit, ensures sensitivity in the picoampere (pA) range in patch clamp, operation equivalent to a bridge amplifier and an extracellular amplifier mode. These devices are designed for a wide range of experimental applications, from intracellular to patch clamp, including extracellular and voltammetry.
Characteristics of theELC patch/electroporation/justacellular recording amplifier series
- High sensitivity preamplifier based on resistive feedback
- Sensitivity down to the picoampere (pA) in patch clamp mode
- Bridge and extracellular mode operation
- Supports electroporation and direct cell stimulation
- Suitable for in vivo and in vitro recording
- Compatible with dyes and transfection protocols
Versions available:
- ELC-01X and ELC-01MX: basic versions with single function for obtaining a Giga seal in patch clamp mode
- ELC-03XS: full version for recording in whole cell and perforated patch mode, ideal for multiprotocol recording and electrical stimulation experiments
Applications
- Recordings with patch pipettes, microelectrodes, metal electrodes or carbon fibres
- High-gain extracellular recordings
- Intracellular recordings in impressed current mode (Bridge)
- Intracellular recordings in imposed potential mode (Voltage Clamp)
- Studies of astrocyte activity
- Experiments combining in vivo whole-cell and multi-electrode extracellular recordings (Neuralynx systems)
- Miniature preamplifiers for in vivo recordings
- Amperometry, voltametry and iontophoresis
- Compatible with most acquisition systems